Backlash St. Louis is an upcoming 2025 professional wrestling event produced by WWE. It will be the 20th Backlash event and will take place on Saturday, May 10, 2025, at the Enterprise Center in St. Louis, Missouri. The event will air via pay-per-view (PPV) and live streaming and feature wrestlers from the Raw and SmackDown brand divisions. This will be WWE's first PPV and live-streaming event held in St. Louis since the 2017 edition of Money in the Bank, which was held at the same venue when it was still known as the Scottrade Center (renamed in 2018). The event concept is based around the immediate fallout from WrestleMania 41. This event will feature John Cena's first appearance at a Backlash event since 2009 (this will also be Cena's last Backlash appearance due to his retirement from professional wrestling at the end of 2025), and also an appearance by Randy Orton in his hometown.